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Linearity performance of the Alinity i TIMP-1 immunoassay across the analytical measuring interval Observed concentrations for gravimetrically prepared dilution levels are plotted against expected values. All levels demonstrated a deviation from linearity within ±10%, confirming linear response throughout the validated range.

Journal: Biochemistry and Biophysics Reports

Article Title: Evaluation of a research use only (RUO) TIMP-1 assay for use with the automated Alinity i platform

doi: 10.1016/j.bbrep.2026.102509

Figure Lengend Snippet: Linearity performance of the Alinity i TIMP-1 immunoassay across the analytical measuring interval Observed concentrations for gravimetrically prepared dilution levels are plotted against expected values. All levels demonstrated a deviation from linearity within ±10%, confirming linear response throughout the validated range.

Article Snippet: We previously developed a research use only (RUO) double monoclonal antibody sandwich TIMP-1 immunoassay to run on the automated ARCHITECT i system (Abbott Laboratories) [ ].

Techniques:

Distribution of TIMP-1 concentrations in normal plasma samples (n = 100) and cardiac specimens with elevated troponin-I (n = 88) The normal donor cohort establishes the physiological concentration range, while cardiac specimens exhibit higher TIMP-1 levels.

Journal: Biochemistry and Biophysics Reports

Article Title: Evaluation of a research use only (RUO) TIMP-1 assay for use with the automated Alinity i platform

doi: 10.1016/j.bbrep.2026.102509

Figure Lengend Snippet: Distribution of TIMP-1 concentrations in normal plasma samples (n = 100) and cardiac specimens with elevated troponin-I (n = 88) The normal donor cohort establishes the physiological concentration range, while cardiac specimens exhibit higher TIMP-1 levels.

Article Snippet: We previously developed a research use only (RUO) double monoclonal antibody sandwich TIMP-1 immunoassay to run on the automated ARCHITECT i system (Abbott Laboratories) [ ].

Techniques: Clinical Proteomics, Concentration Assay